Polymerase recognition of 2-thio-iso-guanine·5-methyl-4-pyrimidinone (iGs·P)—A new DD/AA base pair
نویسندگان
چکیده
منابع مشابه
The fidelity of replication of the three-base-pair set adenine/thymine, hypoxanthine/cytosine and 6-thiopurine/5-methyl-2-pyrimidinone with T7 DNA polymerase.
With the goal of constructing a genetic alphabet consisting of a set of three base pairs, the fidelity of replication of the three base pairs T(H) (5-methyl-2-pyrimidinone)/H(S) (6-thiopurine; thiohypoxanthine), C/H (hypoxanthine) and T/A was evaluated using T7 DNA polymerase, a polymerase with a strong 3'-->5' exonuclease activity. An evaluation of the suitability of a new base pair for replic...
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The anionic base pairs of adenine and thymine, (AT)(-), and 9-methyladenine and 1-methylthymine, (MAMT)(-), have been investigated both theoretically and experimentally in a complementary, synergistic study. Calculations on (AT)(-) found that it had undergone a barrier-free proton transfer (BFPT) similar to that seen in other dimer anion systems and that its structural configuration was neither...
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The variation of thermal and structural properties of 2-{[4-(2-hydroxybenzylideneamino) phenylimino]methyl}phenol (PAM)Schiff base were studied using differential scanning calorimetry (DSC) and powder X-ray diffraction techniques before and after fast neutron (1.050 and 1.740kGy), beta (11.01Gy) and gamma (453.0Gy) irradiations. Under fast neutron irradiation, the melting and decomposition enth...
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Two series (a and b) of N- substituted heteroaromatic compounds related to clotrimazole were synthesized. Imidazole ring of the clotrimazole was replaced by 2-methylimidazole in series a, and by 2-methyl-4-nitroimidazole in series b. O-cholortrityl moiety of clotrimazole was also replaced by trityl, mono or dimethoxy trityl. Chemical structures...
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Sir: Within our primary program specifically oriented to the synthesis of new "2-CH2-X" penem compounds'), we have been engaged in an extensive work=.3> directed towards the simultaneous insertion of the thienamycin and cephalosporin side chains into the penem nucleus. In practice, the conceptual operation of incorporating the heterocyclyl(thio)methyl groups characterizing the most important ce...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2016
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2016.01.041